Vivian Ruvolo Selected Research

bardoxolone methyl

5/2007

The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.

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Vivian Ruvolo Research Topics

Disease

24	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2022 - 11/2005
15	Leukemia 01/2022 - 11/2005
7	Neoplasms (Cancer) 01/2022 - 05/2007
3	AIDS-Related Complex (ARC) 01/2019 - 11/2014
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 01/2022
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 07/2013
2	Neoplasm Metastasis (Metastasis) 01/2020 - 05/2007
2	Hematologic Neoplasms (Hematological Malignancy) 02/2016 - 02/2016
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 03/2014 - 02/2012
2	Carcinogenesis 06/2007 - 05/2007
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2022
1	Inflammation (Inflammations) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 05/2018
1	Infections 12/2017
1	Disease Progression 10/2017
1	Acute Monocytic Leukemia (Acute Monoblastic Leukemia) 01/2017
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 02/2016
1	Hypoxia (Hypoxemia) 12/2013
1	Lymphoma (Lymphomas) 02/2012
1	Breast Neoplasms (Breast Cancer) 05/2007
1	Acute Promyelocytic Leukemia 10/2006

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2005
6	venetoclaxIBA 01/2022 - 03/2014
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2018 - 04/2007
2	ARV-825IBA 01/2022 - 01/2019
2	snake venom protein C activatorIBA 01/2022 - 01/2019
2	Proteolysis Targeting ChimeraIBA 01/2022 - 01/2019
2	Oxygen (Dioxygen)IBA 10/2021 - 01/2017
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2019 - 01/2015
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2018 - 01/2017
2	selinexorIBA 10/2018 - 01/2015
2	LigandsIBA 05/2018 - 04/2016
2	ABT-737IBA 12/2013 - 02/2012
1	Tyrosine Kinase InhibitorsIBA 04/2022
1	Decitabine FDA Link 01/2022
1	Asparaginase (Elspar)FDA Link 01/2022
1	CarbohydratesIBA 01/2022
1	tapotoclaxIBA 01/2022
1	EnzymesIBA 01/2022
1	GlutaminaseIBA 01/2022
1	Glutamine (L-Glutamine)FDA Link 01/2022
1	IACS-010759IBA 01/2022
1	AZD5991IBA 01/2022
1	PND 1186IBA 01/2020
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2019
1	ONC212IBA 12/2019
1	CateninsIBA 01/2019
1	Dinoprostone (PGE2)FDA Link 01/2019
1	Sorafenib (BAY 43-9006)FDA Link 10/2018
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2018
1	Mesylates (Mesylate)IBA 05/2018
1	Biomarkers (Surrogate Marker)IBA 05/2018
1	ChemokinesIBA 04/2016
1	Pharmaceutical PreparationsIBA 04/2016
1	Chemokine ReceptorsIBA 04/2016
1	ibrutinibIBA 02/2016
1	Bortezomib (Velcade)FDA Link 02/2016
1	TIC10 compoundIBA 02/2016
1	RG7112IBA 02/2016
1	nutlin 3IBA 01/2015
1	Adenylate KinaseIBA 01/2015
1	birinapantIBA 11/2014
1	Small Interfering RNA (siRNA)IBA 11/2014
1	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA 12/2013
1	TOR Serine-Threonine KinasesIBA 12/2013
1	LeptinIBA 07/2013
1	Leptin ReceptorsIBA 07/2013
1	Connective Tissue Growth FactorIBA 07/2013
1	MethyltransferasesIBA 12/2012
1	DNA (Deoxyribonucleic Acid)IBA 12/2012
1	fludarabineIBA 02/2012
1	bardoxoloneIBA 06/2010
1	PPAR gammaIBA 06/2010
1	Mediator Complex Subunit 1IBA 06/2010
1	Messenger RNA (mRNA)IBA 06/2010
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 06/2007
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 06/2007
1	Transcription Factors (Transcription Factor)IBA 06/2007
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 05/2007
1	bardoxolone methylIBA 05/2007
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2007
1	TriterpenesIBA 05/2007
1	EstersIBA 05/2007
1	AcidsIBA 05/2007
1	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA 10/2006
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 10/2006
1	Co-Repressor ProteinsIBA 10/2006

Therapy/Procedure

8	Therapeutics 04/2022 - 11/2005
7	Drug Therapy (Chemotherapy) 01/2022 - 05/2007
1	Transplantation 01/2022